Chronic Disseminated Salmonellosis in a Patient With Interleukin-12p40 Deficiency

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چکیده

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"recurrent non-typhoidal salmonella bacteremia in a patient with interleukin -12p40 deficiency "

the south eastern region of iran is an endemic area for salmonellosis. sometimes bacteremia due to nontyphoidal salmonella occurs but certain patients are at increased risk for recurrent bacteremia. the risk of invasive salmonellosis and recurrent bacteremia is increased in the patients with immunosuppression, especially impaired cell-mediated immunity, lymphoproliferative diseases and in patie...

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Recurrent non-typhoidal salmonella bacteremia in a patient with interleukin -12p40 deficiency.

The South eastern region of Iran is an endemic area for salmonellosis. Sometimes bacteremia due to nontyphoidal salmonella occurs but certain patients are at increased risk for recurrent bacteremia. The risk of invasive salmonellosis and recurrent bacteremia is increased in the patients with immunosuppression, especially impaired cell-mediated immunity, lymphoproliferative diseases and in patie...

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Inherited IL-12p40 Deficiency

Autosomal recessive interleukin (IL)-12 p40 (IL-12p40) deficiency is a rare genetic etiology of Mendelian susceptibility to mycobacterial disease (MSMD). We report the genetic, immunologic, and clinical features of 49 patients from 30 kindreds originating from 5 countries (India, Iran, Pakistan, Saudi Arabia, and Tunisia). There are only 9 different mutant alleles of the IL12B gene: 2 small ins...

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ژورنال

عنوان ژورنال: Pediatric Infectious Disease Journal

سال: 2018

ISSN: 0891-3668

DOI: 10.1097/inf.0000000000001701